NGM Biopharmaceuticals, Inc.

NGM‘s initial focus is the discovery and development of novel therapeutics for type 2 diabetes, a disease that afflicts nearly 170 million individuals worldwide. Tragically, this population is expected to more than double in the next 20 years, with undoubtedly devastating humanitarian, social and economic consequences. Current treatments, which have limited efficacy and tolerability, do not adequately address the medical needs of diabetic patients. As newly developed drugs promise only incremental therapeutic advances, alternative approaches are desperately needed.

Type 2 diabetes is a complex disease that results from both impaired insulin secretion from the pancreas and a failure in the body to respond to normal insulin levels (insulin resistance). The inability of the body to adequately manage blood glucose levels is associated with the progressive damage, and ultimate failure, of vital organs, including the eyes, kidneys, nerves and cardiovascular system. Unfortunately, type 2 diabetes continues to be viewed as chronic and irreversible, with the primary treatment goal being the mere management of hyperglycemia rather than remission of the underlying disorder.

Overview – Type 2 Diabetes Gastrointestinal Program Muscle Program		Overview – Type 2 Diabetes NGM‘s initial focus is the discovery and development of novel therapeutics for type 2 diabetes, a disease that afflicts nearly 170 million individuals worldwide. Tragically, this population is expected to more than double in the next 20 years, with undoubtedly devastating humanitarian, social and economic consequences. Current treatments, which have limited efficacy and tolerability, do not adequately address the medical needs of diabetic patients. As newly developed drugs promise only incremental therapeutic advances, alternative approaches are desperately needed. Type 2 diabetes is a complex disease that results from both impaired insulin secretion from the pancreas and a failure in the body to respond to normal insulin levels (insulin resistance). The inability of the body to adequately manage blood glucose levels is associated with the progressive damage, and ultimate failure, of vital organs, including the eyes, kidneys, nerves and cardiovascular system. Unfortunately, type 2 diabetes continues to be viewed as chronic and irreversible, with the primary treatment goal being the mere management of hyperglycemia rather than remission of the underlying disorder.